PHLOJEL® Ultra Efficacy in Transdermal Drug Delivery

PHLOJEL® Ultra Efficacy in Transdermal Drug Delivery

PHLOJEL® Ultra is engineered for optimal transdermal drug delivery, offering rapid skin penetration while minimizing residue and greasiness. This formulation allows for immediate and sustained drug release directly into the target tissue, maximizing therapeutic effects with minimal systemic exposure.

Scientific Evaluation and Outcomes

A clinical study involving 10 healthy volunteers demonstrated the superior transdermal delivery capabilities of PHLOJEL® Ultra compared to traditional Pluronic lecithin organogels (PLO). The study utilized 2% diclofenac sodium, tracking plasma concentration over an 8-hour period. As illustrated in the accompanying graph, plasma levels maintained a relatively stable range of 5-15 ng/mL, indicating consistent drug absorption and minimal systemic distribution.

This controlled release is particularly beneficial when high local concentrations of drugs are necessary. The organogel base forms lecithin depots beneath the epidermis, facilitating a slow and steady release of medication into the bloodstream, ideal for treatments requiring localized action with reduced systemic side effects.